Swedan implies hot fomentation which is also the precursor procedure to Panchkarma which helps in inducing sweating to the patient. This procedure is done to curb the Vata Dosha vitiated due to increase in its Sheeta property. The role of Swedan is best understood with Transient Receptor Potential Channels. These receptors are mainly found in nociceptive neurons of peripheral nervous system. Upon further literary search, it is known that TRPV1 channels are responsible for perception of heat and pain both thereby, facilitating the role of Swedan in Management of pain.