Osteoarthritis (OA) is a very commonest type of arthritis generally found in older age group. Osteoarthritis is known as Sandhi vata in Ayurveda. It is a joint disorder caused by the erosion/ breaking of cartilage that cushion bones at joints and causing pain, swelling and stiffness as bones rub together. The joints most commonly affected are the knees, hips, hands and spine. OA is the leading cause of disability in elderly persons and affects approximately 14-20% of all adults aged ≥25 years. The prevalence rate of OA is 38% in people over 45 years old and 70% in people over 65 years old thus, its prevalence and health impact increase with age. To address the prevalence, cost, and disability associated with OA, multiple organizations have been trying to understand pathogenesis of OA to reduce its incidence and to discover a disease-modifying OA drug that could slow or halt its progression.